USMLE High-Yield Questions on Instagram: "If I don’t open the email the pathology can’t see me ⸻ 🧠 Explanation (high-yield) Smudge cells are fragile mature lymphocytes that rupture during slide preparation. When lymphocytes are numerous and structurally fragile, they crush easily, leaving behind smudged nuclear remnants—a classic peripheral smear clue tested on NBME/USMLE. ⸻ ✅ Answer: C) Chronic lymphocytic leukemia ⸻ ❌ Why the others are wrong • A) Acute myelogenous leukemia → blasts ± Auer ro