Perimenopause is a neuroendocrine transition — a stage where changes in your reproductive hormones directly impact your brain chemistry. Here’s the science: Estrogen supports serotonin for mood stability, dopamine for motivation and reward, and acetylcholine for memory and learning. Progesterone enhances GABA, the calming neurotransmitter that helps regulate anxiety and sleep. When estrogen and progesterone levels fluctuate or decline, neurotransmitter activity shifts. The result? Brain fog from
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