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🧬✨ GDNF Gene Therapy for Parkinson’s ✨🧬 This is about AB-1005 (AAV2-GDNF), a cutting-edge gene therapy in Parkinson’s. ✅ Phase 1b started in 2020, wrapped up Oct 2023 ✅ 11 participants, infused directly into the putamen ✅ Safe well tolerated (no treatment-related serious adverse events over 18–36 months) ✅ Moderate PD: more “Good ON” time, less “OFF” time, reduced dyskinesia—even with lower meds ✅ Mild PD: clinically stable, no worsening ✅ Published in Movement Disorders (May 2025) This trial
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🧬✨ GDNF Gene Therapy: AB-1005 Moves Into Phase 2 REGENERATE-PD ✨🧬 The next chapter is here. Phase 2 is now enrolling for AB-1005 (AAV2-GDNF), a one-time gene therapy infusion targeting the putamen in Parkinson’s disease. ✅ Officially called REGENERATE-PD (NCT06285643) ✅ 2024–2027 study, across the U.S. and Europe ✅ Goal: ~75 participants with mild to moderate Parkinson’s ✅ Randomized, double-blind, placebo-controlled design ✅ Recruiting at top research centers like Duke, UCSF, Mount Sinai, and
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How Ibogaine Promotes GDNF "miracle grow for the brain"? 🧠 Dr. Joseph Barsuglia, clinical researcher and advisor at Beond, highlights the critical role of protein GDNF (Glial-Derived Neurotrophic Factor) in brain regeneration and overall mental health. GDNF, often described as 'miracle grow' for the brain, is vital for nurturing neurons and maintaining crucial brain functions. GDNF is a protein that helps nourish neurons. It is important for neuroplasticity and memory. It helps with brain injur
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