2 days ago · The Independent Review of gender identity services for children and young people (The Cass Review) was commissioned by NHS England to make recommendations about the services provided by the NHS to children and young people who are questioning their gender identity or experiencing gender incongruence and/or gender dysphoria.. In order to better understand the existing evidence base the Review ...

The content of Archives of Disease in Childhood is endorsed by the Royal College of Paediatrics and Child Health for Continued Professional Development in line with RCPCH CPD guidelines. Archives of Disease in Childhood is the flagship of BMJ’s paediatrics portfolio and has an open access companion journal, BMJ Paediatrics Open.For information about the Editor-in-Chief and editorial team ...

Oct 29, 2024 · Frederica Sarantis, Aisosa Osas Guobadia, Marwa A Bebars, Rachana Varma, Jonathon A A Holland, Thiloka Ratnaike

Feb 5, 2025 · Chimeric antigen receptor (CAR) T cell therapy is a promising form of adoptive cell therapy. This process re-engineers patient-derived T cells to express a hybrid receptor targeting a selected tumour-expressed antigen. CAR T cell therapy directed against the CD19 antigen has been highly successful in haematological malignancies that have failed other therapies, particularly relapsed B-cell ...

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Apr 18, 2024 · Characteristics of children requiring admission to neonatal care and paediatric intensive care before the age of 2 years in England and Wales: a data linkage study (12 February, 2024)

Role of the medical examiner service in children and young people’s deaths (4 December, 2024)

6 days ago · Objective In this systematic review and meta-analysis, we assessed and summarised the certainty of the evidence about the effects of gender affirming hormone therapy (GAHT) in individuals with gender dysphoria (GD). Methods We searched Medline, Embase, PsychINFO, Social Sciences Abstracts, LGBTQ+ Source and Sociological Abstracts from inception to September 2023. We included studies comparing ...

Jan 31, 2025 · Objective Complete congenital heart block (CHB) due to anti-Ro/La antibodies in pregnancy can lead to adverse fetal outcomes and neonatal death. National and international guidelines do not recommend specific treatment for women identified with anti-Ro antibodies while pregnant. Design Systematic review of studies of pregnant women with anti-Ro/La antibodies undertaking treatment(s) to prevent ...

Drug resistance and side effects of multidrug therapy for the management of leprosy can cause major issues for patients. Are there shorter, safer options? Barreto J et al [ N Engl J Med 2024;391 (23):2212–2218 DOI: 10.1056/NEJMoa2312928] have presented an adult focused, open-label, study in nine patients from Brazil. They have looked at the drug bedaquline, which blocks the proton pump of ...