A pair of druggie losers reach the top of a hit-list when one witnesses a murder and drags the other into a crazy flight from mobsters.

A stoner (Seth Rogen) is the only witness to a murder committed by a drug lord and crooked cop.

Pineapple Express: Directed by David Gordon Green. With Seth Rogen, James Franco, Danny McBride, Kevin Corrigan. A process server and his marijuana dealer wind up on the run from hitmen and a corrupt police officer after he witnesses his dealer's boss murder a competitor while trying to serve papers on him.

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Judd Apatow's Pineapple Express follows a pair of druggie losers as they reach the top of the hit-list when one witnesses a mob murder and drags his buddy into a crazy flight from mobsters bent on silencing both of them permanently.

A stoner and his dealer are forced to go on the run from the police after the pothead witnesses a cop commit a murder.