Histone deacetylase - Wikipedia
Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH 3) from an ε-N-acetyl lysine amino acid on both histone and non-histone proteins. [2]
Histone Deacetylases (HDACs): Evolution, Specificity, Role in ...
Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences …
Histone deacetylase complexes: Structure, regulation and function
Sep 1, 2024 · Histone deacetylases (HDACs) are key epigenetic regulators, and transcriptional complexes with deacetylase function are among the epigenetic corepressor complexes in the …
Frontiers | The role of HDAC3 in inflammation: mechanisms and ...
Jul 10, 2024 · Histone deacetylases (HDACs) are critical regulators of inflammatory gene expression, and the efficacy of pan-HDAC inhibitors has been implicated in various disease …
Advancements in Hydrazide-Based HDAC Inhibitors: A Review of …
Jul 10, 2025 · Histone deacetylases (HDACs) are crucial enzymes in regulating gene expression by removing acetyl groups from histone proteins. This deacetylation process influences the …
The Histone Deacetylase Family: Structural Features and ... - MDPI
May 10, 2024 · Histone deacetylases (HDACs) are crucial in gene transcription, removing acetyl groups from histones. They also influence the deacetylation of non-histone proteins, …
A short guide to histone deacetylases including recent progress …
Feb 19, 2020 · In this review, current knowledge of HDACs is briefly described with an emphasis on recent progress in research on HDACs, especially on class IIa HDACs. Long eukaryotic …
Regulation of histone deacetylase activities and functions by ...
Jul 18, 2020 · Here we review and critically evaluate how reversible phosphorylation activates or deactivates HDACs and, thereby, regulates their many functions under various cellular and …
HDAC Understanding Histone Deacetylases and Their Role in
Histone Deacetylases (HDACs) play a crucial role in regulating gene expression through epigenetic mechanisms. HDACs remove acetyl groups from histone proteins, leading to …
Definition of HDAC - NCI Dictionary of Cancer Terms
Also called histone deacetylase. An enzyme that removes a small molecule called an acetyl group from histones (proteins found in chromosomes). This changes the way the histones bind to …