A new state-of-the-art diagnostic test for animal African trypanosomiasis could detect sentinels of infection in domestic animals and aid control efforts.

During cell-to-cell spread, HIV-1 protease activity triggers CARD8 inflammasome activation and IL-1β release from macrophages, which may contribute to inflammation and chronic immune activation.

This important study demonstrates the significance of incorporating biological constraints in training neural networks to develop models that make accurate predictions under novel conditions. By ...

The enzyme arginase-II has an important role in cardiac aging, and blocking it could help hearts stay young longer.

Fingertip tactile neurons collectively encode the skin's viscoelastic state alongside current touch, potentially enabling the brain to better interpret forces during manipulation.

This important study investigates frequency-dependent effects of transcutaneous tibial nerve stimulation (TTNS) on bladder function in healthy humans and, through a computational model, shows that low ...

This valuable study concerns a model for transgenerational epigenetic inheritance, the learned avoidance by C. elegans of the PA14 pathogenic strain of Pseudomonas aeruginosa. A recent study ...

Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, United States ...

CPGs. Their model shows that cell-type-specific connectivity and a dominant inhibitory drive could underlie rhythm generation. Excitatory input could act to enhance the frequency range of these ...

This is a potentially valuable modeling study on sequence generation in the hippocampus in a variety of behavioral contexts. While the scope of the model is ambitious, its presentation is incomplete ...

The interferon-induced GTPase GVIN1 prevents bacteria from spreading among cells by coating them and rendering them immobile.

This useful manuscript addresses a stability issue for long-term chronically implanted array recordings and electrolytic lesioning, which is relevant to both basic science and translational research.