A new review finds that ACSL4 currently has the strongest disease-specific evidence among long-chain acyl-CoA synthetases across six female reproductive disorders, while other isoforms remain largely ...

A new study reports that elevated ACOT7 promotes malignant phenotypes in head and neck squamous cell carcinoma by raising ...

The cell nucleus is an active metabolic site. Numerous enzymes best known for their roles in cytosolic or mitochondrial pathways also function in the nucleus, where they contribute to gene regulation ...

Acyl-CoA cholesteryl acyl transferase EC 2.3.1.26, more simply referred to as ACAT, belongs to the class of enzymes known as acyltransferases. The role of this enzyme is to transfer amino-acyl groups ...

What are the 4 steps of beta oxidation? Beta oxidation consists of the following four sequential reactions: 1- Acyl CoA, formed in the mitochondrial matrix, can be oxidized by the enzyme acyl CoA ...

Acyl carrier protein (ACP) plays a central role in fatty acid biosynthesis, acting as a molecular "shuttle" that carries, protects, and delivers elongating acyl chains to various enzymatic partners.

This study examined whether mitochondrial acyl-CoA thioesterase-2 (ACOT2) regulates mitochondrial matrix acyl-CoA levels. Acot2 deletion in murine skeletal muscle (SM) resulted in acyl-CoA build-up.

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceuticeal Sciences, Wuhan University, 185 Donghu Rd., Wuhan 430071, China State Key Laboratory of ...

Posttranslational protein modification by lysine acylation is an emerging mechanism of cellular regulation and fine-tunes metabolic processes to environmental changes. In this review we focus on ...