Another critical service provided by obstetric anaesthesiologists is labour analgesia — the management of labour pain through techniques such as epidural anaesthesia or several alternative options ...

Despite the absence of pain signals, post-operative opioids control tachycardia and hypertension, highlighting the unique challenges in pain-insensitive individuals.

Objective To evaluate the short-term efficacy and safety of methoxyflurane for the treatment of acute pain in patients presenting to an emergency department (ED) with minor trauma. Methods STOP! was a ...

When time to analgesia was dichotomised based on whether analgesia was received within 60 min, 28% of intervention and 32% of control patient (p=0.190) received analgesia within this benchmark. In a ...

Primary and secondary outcome measures The primary outcome was the Face, Legs, Activity, Cry and Consolability (FLACC) Scale Scores. Secondary outcomes included perioperative opioid consumption, the ...

Although acute toxicity was higher for ultra-hypofractionation than conventional fractionation, this long-term patient-reported QOL analysis shows that ultra-hypofractionation was as well tolerated as ...

The patient-doctor relationship is broken. Over 30% of clinic time is spent on administrative tasks, and AI is already cutting that by a third. Yet, technology could be the game-changer.

To tackle this problem, a general redox-controlled site-specific sialylation strategy using Pd2,6ST is described. This approach features site-specific enzymatic oxidation of galactose units to mask ...

The placebo-controlled study period was 48 weeks (including up-titration), followed by an open label extension during which pirfenidone was provided to all patients until the last patient completed ...

We report Pd-catalyzed direct C–H arylation of thiazole, where the regioselective outcome is controlled by the appropriate selection of a base and a ligand. Employing Pd/PPh3/NaOtBu in the reaction ...