Ensuring the safety and quality of pharmaceuticals, such as blood products, vaccines, recombinant proteins, and monoclonal antibodies, is essential. Endotoxins act as a hidden ‘time bomb’ in these ...

Factor XII (Hageman factor) is an important protease that plays a major role in the initiation of the intrinsic pathway of blood coagulation and fibrinolysis and kinin formation. It is still unclear ...

According to GlobalData’s Technology Foresights, which uses over 730,000 patents to analyze innovation intensity for the pharmaceutical industry, there are 80+ innovation areas that will shape the ...

In those with AAV, VTE occurs mainly during periods of active disease, thus implying that hypercoagulability is triggered by endothelial damage and/or vascular inflammation. The authors explored the ...

Moreover, activation of the intrinsic pathway of coagulation on the background of neutrophils and neutrophil extracellular trap (NET) formation appears to be key for COVID-19’s hypercoagulability to ...

In the remaining 16 participants, factor VIII expression was maintained; 12 of these participants were followed for more than 2 years, and a one-stage factor VIII assay showed no apparent decrease ...

Among coagulation factors, a key role seems accomplished by factor XII (FXII), the initiator of the “old” contact (intrinsic) coagulation pathway (11), which cooperates redundantly with the extrinsic ...