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MK-0646 is a humanized IgG1 monoclonal antibody that binds to IGF-1R and is being developed for the treatment of cancer. Methods: In Parts 1 and 2, patients were treated with loading doses of MK-0646 ...
Background Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, ...