Intrinsic apoptosis, also referred as the mitochondrial pathway, is executed in response to cellular damage and most anti-cancer agents, and the B-cell lymphoma 2 or BCL-2 family proteins regulate it.

Unlike intrinsic apoptosis, extrinsic apoptosis is triggered by a signal outside of the cell and requires membrane-spanning proteins called death receptors. 6 The external signal, or death ligand, can ...

Apoptosis is an evolutionary conserved, intrinsic program of cell death that occurs in various physiological and pathological situations (Hengartner, 2000).

This compound activates caspase-2-mediated apoptosis independently of the PIDDosome, requiring BID for its action. Structural specificity of caspase-2 agonists.

High expression of both pro- and antiapoptotic genes predicted poor OS, which postulates a mechanism of activation of the apoptosis pathway as a whole. This mechanism, which culminates in a three-gene ...

In contrast, intrinsic apoptosis is initiated in response to cellular stress and depends on the activation of pro-death proteins (BAK or BAX) which form pores in the mitochondrial membrane.

The intrinsic molecular pathways are also known as mitochondrial or Bcl-2-regulated pathways because they require a bid for apoptosis. This mechanism is associated with the activation of caspase-8 ...

In the intrinsic pathway cellular stress, once detected, causes the cell to self-initiate apoptosis. In the extrinsic pathway, apoptosis is initiated by external signals from other cells.

Apoptosis is an important cellular process that allows cells to die in a programmed fashion, essential for embryo development, homeostasis, and cancer development. This 3D animation provides an ...

Ferroptosis and intrinsic drug-induced liver injury by acetaminophen and other drugs: a critical evaluation and historical perspective Peer-Reviewed Publication Xia & He Publishing Inc.