Naloxone, also known by the brand name Narcan, is one of the most important drugs in the United States' fight against the opioid crisis. It reverses an opioid overdose nearly instantly, restarting ...

Knowing that naloxone works by stalling the µ-opioid receptor in an early, latent state suggests that molecules that can bind more tightly or more selectively to this form of the receptor could be ...