Gut

Rectal lesion with a submucosal tumour-like appearance in a middle-aged woman

A 49-year-old woman had a rectal lesion detected during a screening colonoscopy and was referred to our institution for ...
gut.bmj

Sulphation and secretion of the predominant secretory human colonic mucin MUC2 in ulcerative colitis

a Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of Amsterdam, Academic Medical Centre, Amsterdam, The Netherlands, b Pediatric Gastroenterology and Nutrition, ...
gut.bmj

Fukuoka criteria accurately predict risk for adverse outcomes during follow-up of pancreatic cysts presumed to be intraductal papillary mucinous neoplasms

Correspondence to Dr Suresh T Chari, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA; chari.suresh{at}mayo.edu Objective Fukuoka ...
Gut

Molecular and cellular consequences of tumour-autonomous IL-6 signalling in intrahepatic cholangiocarcinoma

Background High serum levels of interleukin 6 (IL-6) predict poor prognosis in intrahepatic cholangiocarcinoma (iCCA), a ...
gut.bmj

PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury

Objectives Autoimmune hepatitis (AIH) is a severe necroinflammatory liver disease associated with significant mortality. Although loss of hepatocytes is generally recognised as a key trigger of liver ...
Gut

Comment on: Therapeutic inhibition of HBsAg and HBV cccDNA through a novel phased combination treatment: glycine and interferon-α

We read with great interest the recent study by Lin Huang and colleagues, which demonstrates that glycine supplementation ...
gut.bmj

Vonoprazan-based versus proton pump inhibitor-based therapy in Helicobacter pylori eradication: an updated systematic review and meta-analysis of randomised trials

We read the Maastricht VI/Florence consensus report published in GUT with great interest.1 The report suggested that vonoprazan-based therapy is superior, or not inferior, to conventional proton pump ...
gut.bmj

Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networks

3 College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA Objective Despite widespread use of antibiotics for the treatment of life-threatening infections and for research on ...
gut.bmj

Targeting MXD1 sensitises pancreatic cancer to trametinib

4 Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China 5 Department of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research ...
gut.bmj

Twenty-four-week anti-PD-1 antibody regimen promoted HBsAg reduction and concurrently enhanced HBV-specific T cell responses in patients with chronic hepatitis B

Background PD-1 blockade has emerged as a promising approach for functional cure of chronic hepatitis B (CHB). Objective This study aimed to evaluate the safety profile of anti-PD-1 antibody (αPD-1), ...
gut.bmj

Functional bowel disorders and functional abdominal pain

The Rome diagnostic criteria for the functional bowel disorders and functional abdominal pain are used widely in research and practice. A committee consensus approach, including criticism from ...
gut.bmj

Vonoprazan prevents low-dose aspirin-associated ulcer recurrence: randomised phase 3 study

Objective Compare efficacy and safety of vonoprazan and lansoprazole for secondary prevention of low-dose aspirin (LDA)-associated peptic ulcers in a 24-week study and long-term extension therapy in ...