Gut

Real-world evidence supports earlier treatment in HBeAg-positive but not HBeAg-negative chronic hepatitis B virus infection

In chronic hepatitis B virus (HBV) infection, the central debate remains whom and when to treat. The 2025 European ...
Gut

From IPMN to invasive pancreatic cancer: new spatial insights

Early detection and interception of pancreatic ductal adenocarcinoma (PDAC) remain the only realistic strategies to reduce ...
gut.bmj

Efficacy of endoscopic screening for esophageal cancer in China (ESECC): design and preliminary results of a population-based randomised controlled trial

Correspondence to Professor Hong Cai and Professor Yang Ke, Laboratory of Genetics, Peking University Cancer Hospital and Institute, Beijing 100142, China; drhcai{at}gmail.com, keyang{at}bjmu.edu.cn ...
gut.bmj

Epidemiology of chronic liver diseases in the USA in the past three decades

Objective Given significant advances in treatment of viral hepatitis and the growing epidemic of obesity, the burden of the different types of liver diseases in the USA may be changing. Our aim was to ...
Gut

Kupffer cell autophagy emerges as a central regulator of immune dysregulation in primary biliary cholangitis

Primary biliary cholangitis (PBC) is a rare chronic autoimmune cholangiopathy that mainly affects middle-aged women, ...
gut.bmj

Surveillance guidelines after removal of colorectal adenomatous polyps

1 Cancer Research UK Colorectal Cancer Unit, St Mark’s Hospital, Harrow, Middlesex HA1 3UJ, UK 2 Wolfson Unit for Endoscopy, St Mark’s Hospital Most colon cancers are assumed to have a premalignant ...
Gut

NSUN6 deficiency drives immune suppression in pancreatic cancer via the KDM5A-CCL2-macrophage axis

Background RNA 5-methylcytosine (m5C) has emerged as a critical epigenetic regulator in cancer biology, yet its role in the tumour immune microenvironment (TME) remains incompletely understood.
Gut

Colorectal cancer in metabolic dysfunction-associated steatotic liver disease: an international Delphi consensus statement

Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide. Epidemiological evidence indicates that MASLD is associated with an ...
gut.bmj

Chimeric antigen receptors of HBV envelope proteins inhibit hepatitis B surface antigen secretion

1 Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Frontier Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, ...
gut.bmj

Treatment of non-constipated irritable bowel syndrome with the histamine 1 receptor antagonist ebastine: a randomised, double-blind, placebo-controlled trial

Correspondence to Professor Guy Boeckxstaens, Department of Chronic Diseases, Metabolism, and Ageing, KU Leuven, Leuven, Belgium; guy.boeckxstaens{at}kuleuven.be Objective We evaluated the histamine 1 ...
Gut

Indole-3-propionic acid links gut dysfunction to diabetic retinopathy: a biomarker and novel therapeutic approach

Background Both host and microbe metabolism of tryptophan (Trp) is altered in diabetes; however, the molecular mechanisms are ...
gut.bmj

Measuring size of smaller colorectal polyps using a virtual scale function during endoscopies

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