gut.bmj

Clinical disease activity, C-reactive protein normalisation and mucosal healing in Crohn's disease in the SONIC trial

Background and aims The Crohn's Disease Activity Index (CDAI) has been criticised due to heavy weighting on subjective clinical symptoms. C-reactive protein (CRP) and endoscopic lesions are objective ...
gut.bmj

Roseburia inulinivorans increases muscle strength

Background Gut bacteria have been implicated in a wide range of health conditions, yet their potential role in preventing and treating muscle-wasting disorders remains largely unexplored. Objective We ...
Gut

Appearances can be deceiving: an ulcerated oesophageal lesion

An 82-year-old man with alcohol-related cirrhosis (Child-Pugh class B), complicated by portal hypertension and a history of partial gastrectomy with Billroth I reconstruction for duodenal ulcer ...
gut.bmj

Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn’s disease

Objective Intestinal barrier loss is a Crohn’s disease (CD) risk factor. This may be related to increased expression and enzymatic activation of myosin light chain kinase 1 (MLCK1), which increases ...
gut.bmj

CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies

1 Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, and Harvard Medical School, Boston, MA, USA 2 ...
gut.bmj

UK key performance indicators and quality assurance standards for colonoscopy

Colonoscopy should be delivered by endoscopists performing high quality procedures. The British Society of Gastroenterology, the UK Joint Advisory Group on GI Endoscopy, and the Association of ...
Gut

Are the drugs already on the shelf? Repurposing therapy for pancreatitis

The persistent absence of disease-modifying therapy for recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) represents one of the more conspicuous therapeutic gaps in gastroenterology.
Gut

Impairment of Rab7-dependent STING degradation hampers HBV replication but accelerates disease progression in chronic hepatitis B comorbid with MASLD

Background Concomitant metabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent in patients with chronic ...
gut.bmj

Twenty-four-week anti-PD-1 antibody regimen promoted HBsAg reduction and concurrently enhanced HBV-specific T cell responses in patients with chronic hepatitis B

Background PD-1 blockade has emerged as a promising approach for functional cure of chronic hepatitis B (CHB). Objective This study aimed to evaluate the safety profile of anti-PD-1 antibody (αPD-1), ...
gut.bmj

Cigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites

Correspondence to Professor Jun Yu, Institute of Digestive Disease, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; ...
gut.bmj

Correction: Congenital sucrase-isomaltase mutations worsen IBS-linked V15F dysfunction and trafficking

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be ...
gut.bmj

Oleic acid promotes lung injury in hypertriglyceridaemia-associated acute pancreatitis via the PIEZO1/NR4A1/CPT1A axis impairing endothelial fatty acid oxidation

Background Hypertriglyceridaemia-induced acute pancreatitis (HTG-AP) is frequently complicated by acute lung injury (ALI), which worsens prognosis. Oleic acid (OA), a major circulating free fatty acid ...