Objective The interleukin (IL)23 pathway contributes to IBD pathogenesis and is being actively studied as a therapeutic target in patients with IBD. Unexpected outcomes in these therapeutic trials ...
Objectives Gastro-oesophageal reflux symptoms are common in the community, but there has been no definitive systematic review and meta-analysis of data from all studies to estimate their global ...
3 Department of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy Correspondence to Dr Maria Rescigno, Department of Experimental Oncology, European Institute of Oncology ...
Background Gut microbiota dysbiosis is linked to autism spectrum disorder (ASD) in children. However, the role of bacterial ...
Is gastric cancer becoming a rare disease? A global assessment of predicted incidence trends to 2035
Objectives The incidence of gastric cancer continues to decrease globally, approaching levels that in some populations could define it as a rare disease. To explore this on a wider scale, we predict ...
Background Metabolic dysfunction associated steatotic liver disease (MASLD), the most common chronic liver disease globally, may originate early in life. While maternal obesity is linked to offspring ...
Objective Bile acids are regulators of lipid and glucose metabolism, and modulate inflammation in the liver and other tissues. Primary bile acids such as cholic acid and chenodeoxycholic acid (CDCA) ...
3 NHS Bowel Cancer Screening Midlands and North West Programme Hub, Rugby, UK 4 NHS Bowel Cancer Screening Southern Programme Hub, Guildford, UK 5 University of Surrey, Guildford, UK Correspondence to ...
Background Depending on the colorectal cancer (CRC) screening programme, a colonoscopy should be performed within 1–3 months after a positive faecal immunochemical test (FIT) result. However, such ...
With great interest, we read the review article by Agus et al , which suggested that gut microbiome alterations could affect metabolic homeostasis.1 Moreover, gut microbiome alterations in concert ...
1 Department of Gastroenterology, University Hospital CHU of Liège, Liège, Belgium 2 Department of Gastroenterology, University Hospital of Cordoba, Cordoba, Spain Crohn's disease is characterised by ...
Objective Proton pump inhibitors (PPIs) are drugs used to suppress gastric acid production and treat GI disorders such as peptic ulcers and gastro-oesophageal reflux. They have been considered low ...
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