gut.bmj

Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model

3 Department of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy Correspondence to Dr Maria Rescigno, Department of Experimental Oncology, European Institute of Oncology ...
Gut

Bacterial genomic structural variations in children with autism serve as diagnostic biomarkers

Background Gut microbiota dysbiosis is linked to autism spectrum disorder (ASD) in children. However, the role of bacterial ...
gut.bmj

Emerging treatment options for extraintestinal manifestations in IBD

Correspondence to Dr Stephan R Vavricka, Gastroenterology and Hepatology Center, Zurich, Switzerland; stephan.vavricka{at}usz.ch; Dr Thomas Greuter, Department of Gastroenterology and Hepatology, ...
gut.bmj

Liquid biopsies to track trastuzumab resistance in metastatic HER2-positive gastric cancer

Objective To monitor trastuzumab resistance and determine the underlying mechanisms for the limited response rate and rapid emergence of resistance of HER2+ metastatic gastric cancer (mGC). Design ...
gut.bmj

Functional bowel disorders and functional abdominal pain

The Rome diagnostic criteria for the functional bowel disorders and functional abdominal pain are used widely in research and practice. A committee consensus approach, including criticism from ...
gut.bmj

Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD

Objective Bile acids are regulators of lipid and glucose metabolism, and modulate inflammation in the liver and other tissues. Primary bile acids such as cholic acid and chenodeoxycholic acid (CDCA) ...
gut.bmj

Increased uptake and improved outcomes of bowel cancer screening with a faecal immunochemical test: results from a pilot study within the national screening programme in England

3 NHS Bowel Cancer Screening Midlands and North West Programme Hub, Rugby, UK 4 NHS Bowel Cancer Screening Southern Programme Hub, Guildford, UK 5 University of Surrey, Guildford, UK Correspondence to ...
gut.bmj

Does a long time to colonoscopy after a positive faecal immunochemical test result have a deleterious impact on colorectal cancer outcomes? A nationwide cohort study

Background Depending on the colorectal cancer (CRC) screening programme, a colonoscopy should be performed within 1–3 months after a positive faecal immunochemical test (FIT) result. However, such ...
gut.bmj

Hidden link in gut–joint axis: gut microbes promote rheumatoid arthritis at early stage by enhancing ascorbate degradation

With great interest, we read the review article by Agus et al , which suggested that gut microbiome alterations could affect metabolic homeostasis.1 Moreover, gut microbiome alterations in concert ...
Gut

Rise of prediagnostic molecular profiling in inflammatory bowel disease—can we close the door before the horse has bolted?

Inflammatory bowel disease (IBD) is typically diagnosed after the onset of symptoms in the context of established, characteristic patterns of intestinal inflammation. However, there is now substantial ...
gut.bmj

Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: a population study using proton-magnetic resonance spectroscopy and transient ...

1 Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China 2 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China 3 Department of ...
gut.bmj

Preclinical stages of Crohn’s disease defined by faecal calprotectin in asymptomatic first-degree relatives

We read with great interest the recent article by Turner et al published in Gut , which evaluated the use of faecal calprotectin to define preclinical stages of Crohn’s disease (CD) in asymptomatic ...