BMJ1d
Normal human enthesis harbours conventional CD4+ and CD8+ T cells with regulatory features and inducible IL-17A and TNF expression
1 University of Leeds Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, UK Background The human enthesis conventional T cells are poorly characterised. Objectives To study the biology ...
BMJ1d
Risk of severe herpes simplex virus infection in systemic lupus erythematosus: analysis of epidemiology and risk factors analysis in Taiwan
Objective Patients with systemic lupus erythematosus (SLE) are susceptible to herpes simplex virus (HSV) infection, which occasionally leads to severe complications including meningoencephalitis and ...
BMJ3d
Differential effects of leflunomide and methotrexate on cytokine production in rheumatoid arthritis
1 Division of Clinical Immunology and Rheumatology, Academic Medical Centre/University of Amsterdam, Amsterdam, The Netherlands 2 Department of Rheumatology, Leiden University Medical Centre, Leiden, ...
BMJ3d
Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis
Correspondence to Dr Tristan Maerz, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA; tmaerz{at}med.umich.edu Objectives Synovium is acutely affected following joint ...
BMJ10d
Fatigue in patients with early rheumatoid arthritis undergoing treat-to-target therapy: predictors and response to treatment
Objectives Fatigue is a frequent symptom in rheumatoid arthritis (RA) and has high impact on quality of life. We explored associations between disease activity and fatigue in patients with early RA ...
BMJ11d
Type II collagen facilitates gouty arthritis by regulating MSU crystallisation and inflammatory cell recruitment
Objective Increasing evidence suggests that impaired cartilage is a substantial risk factor for the progression from hyperuricaemia to gout. Since the relationship between cartilage matrix protein and ...
BMJ8d
Validation of EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient indexes (ESSPRI)
1 Center of Clinical Epidemiology, Hôpital Hotel Dieu; INSERM U738, Université Paris-René Descartes, Paris, France Objectives To validate the two recently developed disease activity indexes for ...
BMJ8d
Burden and trajectory of multimorbidity in rheumatoid arthritis: a matched cohort study from 2006 to 2015
Correspondence to Dr Bryant R England, Division of Rheumatology & Immunology, University of Nebraska Medical Center, Omaha, NE 68198, USA; bryant.england{at}unmc.edu Objectives To compare the onset ...
BMJ4d
AB0306 IMPACT OF TOFACITINIB ON LIPID METABOLISM IN PATIENTS WITH RHEUMATOID ARTHRITIS: A REAL-WORLD STUDY
Background Tofacitinib is the first Janus Kinase (JAK) inhibitor available in China, and it has significantly improved the efficacy of treatment of rheumatoid arthritis (RA). Previous clinical trials ...
BMJ3d
Taxonomy of fibroblasts and progenitors in the synovial joint at single-cell resolution
Objectives Fibroblasts in synovium include fibroblast-like synoviocytes (FLS) in the lining and Thy1+ connective-tissue fibroblasts in the sublining. We aimed to investigate their developmental origin ...
BMJ9d
POS0912 SARCOPENIA IN SPONDYLOARTHRITIS. ULTRASOUND EVALUATION
Background Spondyloarthritis are a group of chronic inflammatory rheumatic diseases that share clinical and imaging characteristics. Sarcopenia is characterized by loss of muscle mass and function ...
BMJ4y
Contrasting contributions of TNF from distinct cellular sources in arthritis
2 Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology RAS, Moscow, Russian Federation Objectives Neutralisation of tumour necrosis ...