Enterocutaneous fistulae (ECF) are challenging problem commonly encountered by surgeons and cause significant complications. They not only prolong hospital stay, but also restrict a patient’s ...

Ensuring the safety and quality of pharmaceuticals, such as blood products, vaccines, recombinant proteins, and monoclonal antibodies, is essential. Endotoxins act as a hidden ‘time bomb’ in these ...

Objectives Intrinsic capacity (IC) was proposed by the WHO as a new concept for capturing an individual’s functional capacities across their lifetime. We aimed to investigate the prevalence and ...

Historically, the clotting cascade has been described as being initiated by either the intrinsic or the extrinsic pathway, ... Depletion of clotting factors and platelets will occur, ...

Daily supplementation with 3 g of EPA/DHA for 12 weeks, and especially after 18 weeks, inhibits tissue factor activity in adherent monocytes (a catalyst in the coagulation cascade); this benefit also ...

Hemophilia A and B coagulation defects, which are caused by deficiencies of Factor VIII and Factor IX, respectively, can be bypassed by administration of recombinant Factor VIIa. However, the ...

With sufficient factor XIIa, factor XI is activated, triggering thrombin generation and fibrin formation via the intrinsic pathway, with dampening of the fibrinolytic pathway via activation of ...

These platelet plugs are loose and require stabilization by cross-linked fibrin clots, which are generated through coagulation. Under physiological conditions, following vascular injury, extravascular ...