Hemophilia A and B coagulation defects, which are caused by deficiencies of Factor VIII and Factor IX, respectively, can be bypassed by administration of recombinant Factor VIIa. However, the ...

A high-throughput workflow for wide-targeted metabolomics in dried blood spots (DBS) is presented.

These platelet plugs are loose and require stabilization by cross-linked fibrin clots, which are generated through coagulation. Under physiological conditions, following vascular injury, extravascular ...

Coagulation factor deficiencies, such as those affecting factor V, result in impaired clot formation and can manifest in varying severities of bleeding disorders. In contrast, ...

Historically, the clotting cascade has been described as being initiated by either the intrinsic or the extrinsic pathway, ... Depletion of clotting factors and platelets will occur, ...

Scientists from Cincinnati Children's and colleagues based in Japan report achieving a major step forward in organoid ...

Ensuring the safety and quality of pharmaceuticals, such as blood products, vaccines, recombinant proteins, and monoclonal antibodies, is essential. Endotoxins act as a hidden ‘time bomb’ in these ...

Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. Lancet 1995;345:152-155. Crossref. PubMed. Web of Science. Google Scholar. 2.

Navigating the Artificial Blood Cells MarketIn the landscape of modern medicine, few innovations hold the transformative ...

Background: Factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are associated with risk of arterial and venous thrombosis and with hemorrhagic disorders. We aimed to identify and ...

Investigators evaluated the efficacy and safety of different doses of MK-2060, a monoclonal antibody against Factor XI, to prevent vascular access clotting in patients receiving hemodialysis via an ...

Objective To review and frequently update the available evidence on injury risk factors and epidemiology of injury in trail running. Design Living systematic review. Updated searches will be done ...