Ensuring the safety and quality of pharmaceuticals, such as blood products, vaccines, recombinant proteins, and monoclonal antibodies, is essential. Endotoxins act as a hidden ‘time bomb’ in these ...

MK-0646 is a humanized IgG1 monoclonal antibody that binds to IGF-1R and is being developed for the treatment of cancer. Methods: In Parts 1 and 2, patients were treated with loading doses of MK-0646 ...

Background Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, ...