BOSTON, April 10, 2025 /PRNewswire/ -- Intrinsic Therapeutics, a medical technology company driving to change the standard of care for lumbar discectomy patients with large annular defects by reducing ...

Ferroptosis and intrinsic drug-induced liver injury by acetaminophen and other drugs: a critical evaluation and historical perspective Peer-Reviewed Publication Xia & He Publishing Inc.

Endothelial cell apoptosis in vessel pruning/regression is mediated by extrinsic apoptosis pathway and intrinsic apoptosis pathway that leads to the activation of the BAK (BCL-2 [B-cell lymphoma ...

To promote apoptosis is one of the promising targets of antitumor drug research. In general, antitumor agents induce apoptosis in tumor cells mainly through two pathways: the mitochondria-mediated ...

Indeed, we found that imipridones reversed HDAC-inhibitor induced activation of cellular respiration and in turn the combination treatment facilitated induction of intrinsic apoptosis in a manner ...

Unlike intrinsic apoptosis, extrinsic apoptosis is triggered by a signal outside of the cell and requires membrane-spanning proteins called death receptors. 6 The external signal, or death ligand, can ...

Lycorine-nanoparticles (LYC-NPs) were successfully synthesized using anti-solvent precipitation-freeze drying method, and characterized using transmission electron microscopy (TEM), particle size ...

In this review, we will focus on the emerging concept of inhibiting intrinsic apoptosis. We will describe the molecular machineries in mitochondrial apoptosis and discuss the exciting therapeutic ...

However, due to several challenges, pharmacological inhibition of apoptosis is still only a recently emerging strategy to combat pathological cell loss. Here, we describe several key steps in the ...