Cellular senescence is a state where cells permanently stop dividing but remain metabolically active, often in response to stress or damage. Senescent cells are known to play a key role in wound ...

T cell senescence occurs in the TME, affecting cancer prognosis and immunotherapy efficacy. The TME induces T cell senescence through multiple pathways, including persistent stimulation by ...

Aging cells secrete substances known to promote the growth of cancer cells. The development of drugs that can selectively kill these cells or inhibit the secretion of substances is ongoing. The latest ...

Natural Killer (NK) cells are vital immune defenders that target and destroy cancer cells. However, in aging and cancer patients, NK cells often become "senescent"—losing their effectiveness due to ...

Scientists at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, have found that gene editing using CRISPR-Cas9 in combination with AAV6 vectors can trigger inflammatory and ...

The key to reversing cellular aging may lie in a protein responsible for toggling cells between a "young" and an "old" state. This is the conclusion of researchers from the University of Osaka, who ...

Proteins that trigger cell senescence occupy much of the literature on aging, but a small RNA moves into the limelight. Further investigation into SNORA13 revealed that it modifies RNA bases in the ...

Diminishing energy production in aging neurons triggers senescence in nearby glial cells, which ordinarily support and protect neurons. With age, some cells in the brain enter a state of senescence: ...