A change in one gene can disrupt thousands of others in HD. A study in pigs suggests an explanation: expanded huntingtin ...

Its speech measures reflected clinical scores and HD-related changes over time, suggesting it could be used as a remote ...

Regular HDBuzz readers may recall our September 2024 article examining the long history of pridopidine in Huntington’s disease (HD) research. In that piece, we covered the drug’s journey through four ...

In plain language. Written by scientists. Scientists discovered that a specific type of brain cell becomes unusually quiet in Huntington’s disease. By restoring the activity of these cells in mice, ...

In an update from uniQure, they report that their experimental gene therapy, AMT-130, has the potential to slow Huntington’s disease progression in key clinical study. HD is caused by a faulty copy of ...

March brought us the annual CHDI therapeutics conference along with updates from 3 ongoing clinical trials. We also covered new research on somatic expansion and honored the community that built our ...

New research in a HD mouse model points to a key culprit: a small fragment called HTT1a. Lowering HTT1a levels successfully delayed disease signs in mice that model HD, perhaps shaping the next ...

A highly-anticipated scientific paper has landed! This new work challenges current theories in Huntington’s disease research, uncovering how runaway CAG repeats erode cell identity in certain types of ...

Day 1 of HD2026 is a wrap! From what human brains can teach us about HD, to HTT1a, somatic CAG expansion and the normal biology of HTT, today’s talks spanned the spectrum from fundamental biology to ...

The outcomes of the SELECT-HD clinical trial are out, with encouraging news for this allele-selective huntingtin lowering therapy This approach does have some drawbacks. Everyone who is interested in ...

After receiving a high dose of uniQure’s gene therapy for Huntington’s disease, a few patients experienced serious side effects, but are now recovering. HDBuzz explores what this means for the ...

Day 2 of #HD2026 brought us updates on the mechanics of somatic instability, new ways to track HD in people, AI tools to help drive research forward, and developments in our understanding of the HTT ...