A study by Children's Medical Research Institute (CMRI) researchers reveals a new group of proteins that guide the powerful enzyme telomerase, opening potential doors to novel treatments for cancer, ...

Inappropriate activation of a single enzyme, telomerase, is associated with the uncontrollable proliferation of cells seen in as many as 90 percent of all of human cancers. Scientists have long eyed ...

Researchers have described for the first time a key target of DNA damage checkpoint enzymes that must be chemically modified to enable stable maintenance of chromosome ends by telomerase, an enzyme ...

Telomerase is an important drug target for cancer. It is expressed in most tumours from virtually all types of cancers and is required for long-term maintenance of telomeres, which in turn is crucial ...

Of the many components in the cell thought to play a role in cancer, few have received more attention in recent years than an enzyme that has been dubbed a cellular fountain of youth. Known as ...

Imetelstat, a 13-mer oligonucleotide that is covalently modified with lipid extensions, competitively inhibits telomerase enzymatic activity. It has been shown to inhibit megakaryocytic proliferation ...

Researchers at the University of California, Berkeley have published the first detailed image of the molecular structure of human telomerase, the enzyme that lengthens chromosomes and extends the ...

A telomere is a region of repetitive nucleotide sequences associated with specialized proteins located at the ends of linear eukaryotic chromosomes to protect the chromosomes from progressive ...

This year's Nobel Prize in medicine went to a trio of scientists who discovered the enzyme telomerase, which allows cells to divide without any limits, making them effectively immortal. It may be ...

Idiopathic pulmonary fibrosis is progressive and often fatal; causes of familial clustering of the disease are unknown. Germ-line mutations in the genes hTERT and hTR, encoding telomerase reverse ...