Shop 2021 Mercedes-Benz S-Class vehicles for sale at Cars.com. Research, compare, and save listings, or contact sellers directly from 206 2021 S-Class models nationwide.

Mercedes-Benz discontinued its flagship grand tourer coupe and convertible, but that still doesn't keep us from missing them.

Comparison between a 2021 Mercedes-AMG E63S and a 2011 Mercedes E350 Sport. I compare the newly redesigned 2021 Mercedes-AMG ...

That's a year later than normal for a mid-cycle refresh at Mercedes, which traditionally comes after four years (the current S-Class, the W223 generation, debuted in 2020 as a 2021 model).

Shop hybrid 2021 Mercedes-Benz S-Classs for sale at Cars.com. Research, compare, and save listings, or contact sellers directly from 24 hybrid 2021 Mercedes-Benz S-Classs nationwide.