Most molecules that would stabilize mRNA against pH-mediated degradation would, furthermore, likely be hazardous chemicals. The key to successful LNP production, therefore, is minimization of the time ...

The mRNA therapeutics field is rapidly evolving beyond vaccines to include treatments for cancer, genetic disorders and in vivo cell therapies, bringing with it diverse production challenges. As the ...

In the first segment of this GEN webinar, Yasser Kehail will highlight Aldevron’s newly expanded sequence-to-vial mRNA ecosystem. Next, the webinar will focus on Precision Nanosystems' Genomic ...

Colin McKinlay, the senior director of Chemistry and Delivery Technologies at Nutcracker Therapeutics, discusses current challenges in mRNA and LNP manufacturing as well as innovations that meet these ...

These trends, along with intensified global efforts in product development, are driving innovation, expanding manufacturing capacity, and strengthening the global mRNA synthesis and production market.

In a study in Nature Communications, Mitchell, Padilla and their collaborators demonstrate that BEND lipids improve LNP delivery of mRNA and gene-editing tools, in some cases by as much as tenfold.

The ionizable, cationic lipid has multiple roles such as promoting the encapsulation of mRNA during the LNP synthesis process and also for endosomal escape; releasing the mRNA into the cytosol.

As we previously discussed, beginning in 2022, a series of patent infringement lawsuits were filed against Moderna and collaborators Pfizer+BioNTech ...

Press Releases Applied DNA to Showcase Linea IVT as a High-yield, dsRNA-Mitigated Platform for the GMP Manufacture of RNA at the 3rd Annual mRNA Process Development & Manufacturing Summit ...