The mammalian elongation complex has remained a mystery – until researchers discovered how it controls its speed.

Transcription factors are an essential part of gene expression. Some of these proteins are known as master regulators, and they can have an impact on many different biochemical pathways and processes ...

Scientists used the auxin-inducible degron 2 system on CTCF, bringing the novel approach to bear on a fundamental protein. CTCF is a critical protein known to play various roles in key biological ...

Life's instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads the script, transcribing RNA in eukaryotic cells and eventually giving rise to proteins. Scientists ...

Our DNA contains thousands of genes, and it is critical that the correct genes are expressed in the right places at the proper time. Our cells have a variety of ways to control gene expression, one of ...

St. Jude Children’s Research Hospital scientists have revealed a previously unknown role for CTCF, a pivotal transcription regulator linked to cancer. CTCF is known by biologists for being a master ...

DNA, the long polymer curled up inside our cells, is often described as the instructions for life. But those instructions are stored in DNA’s chemical code, and reading that code requires the ...

to the project ‘Targeting transcription elongation to modify the prostate cancer tumor immune micro-environment’ to the research group Transcriptional Rewiring in Cancer led by Harri Itkonen ...

Researchers have found a small but powerful switch inside breast cancer cells that helps them survive stressful conditions.

(Memphis, Tenn.—January 25, 2023) CTCF is a critical protein known to play various roles in key biological processes such as transcription. Scientists at St. Jude Children’s Research Hospital used a ...