Enzymes that cut DNA at specific sites are called endonucleases; these enzymes play many roles in genomic replication, fidelity, and defense. The initial discovery of restriction endonucleases in the ...

In the early 1950s, experiments by two teams of researchers, Salvador Luria working with Mary Human and Joe Bertani working with Jean Weigle, showed that some strains of bacteria were more resistant ...

Because these enzymes are small and specific, they could become powerful tools in the lab. They could improve rolling circle amplification (RCA), a process used to copy DNA for tests. Scientists have ...

Restriction enzymes are essential tools for recombinant DNA technology that have revolutionized modern biological research; however, they have limited sequence specificity and availability. The ...

EcoR124I is a type I DNA restriction and modification enzyme. The single-molecule magnetic tweezers technique reveals that this sophisticated molecular machine is capable of moving thousands of base ...

Restriction-modification systems are important defenses against interspecies and even intraspecies uptake of exogenous and potentially harmful (e.g., bacteriophage) DNA. To date, four types of ...

There are many health problems that can be traced back to errors in the genetic code. There are also many potential benefits to genetic engineering outside of healthcare. Nature has already found ways ...

Most gene-editing tools cut DNA wherever they’re pointed, with no way to tell a tumor cell from a healthy one. A study ...