A new study shows that both inhibiting and activating the metabolic enzyme PKM2 reduces nuclear accumulation of the protein, ...

An article in Protein & Cell discusses the multifactorial nature of obesity, highlighting its association with chronic low-grade inflammation, or meta-inflammation, which contributes to metabolic ...

The present study was instituted to determine whether children with congenital heart disease have abnormal blood levels of lactate and pyruvate and to determine whether a relation exists between ...

Endogenous pyruvate is an end-product in glycolysis and a key molecule for ATP production under aerobic and anaerobic conditions, whereas exogenous pyruvate is transferred to cells via monocarboxylate ...

Image Caption: Pyruvate inhibits TNFα/NF-κB signaling and the expression of downstream pro-inflammatory genes. Genes & Diseases publishes rigorously peer-reviewed and high quality original articles ...

A cellular fuel called lactate is channelled directly into energy-generating organelles in heart muscle, defying the ...

Pyruvate kinase deficiency is a rare, hereditary, chronic condition that is associated with hemolytic anemia. In a phase 2 study, mitapivat, an oral, first-in-class activator of erythrocyte pyruvate ...