In recent years, our understanding of the molecular basis of kidney development has benefited from the study of rare genetic diseases affecting renal function. This has especially been the case with ...

A team of scientists now reports an approach that enables the differentiation of human induced pluripotent stem (iPS) cells into mature podocytes with more than 90 percent efficiency. Linking the ...

Using 2-DOG uptake assays, we found that two independent podocyte cell lines were each capable of increasing their glucose uptake by 90 and 105%, respectively, after 15 min of stimulation with 220 ...

Podocytes are a terminally differentiated cell type located in the glomerulus. Podocyte damage and the subsequent dysregulation of podocyte proteins have been implicated in various kidney disorders.

Human stem cells are of great interest in the fields of regenerative medicine and medical research because they reproduce indefinitely and can differentiate into every other cell type found in the ...

Richard J.M. Coward; Gavin I. Welsh; Jing Yang; Candida Tasman; Rachel Lennon; Ania Koziell; Simon Satchell; Geoffrey D. Holman; Dontscho Kerjaschki; Jeremy M ...