1 The papillary muscles, as integral parts of the mitral apparatus, are extremely vulnerable to ischemic injury because of the great mechanical stress to which they are subjected ...

Rheumatic heart disease (RHD ... but normal valves can also be involved. Papillary muscle dysfunction from ischemia, infarction or rupture may occur in patients with coronary artery disease ...

We now find that DOXol is cardioactive, increasing resting stress in isometrically contracting papillary muscles isolated from rabbit heart. Values in the table were measured after the addition of ...