Peptide nucleic acids (PNAs) represent a revolutionary class of synthetic nucleic acid analogues, in which the traditional sugar–phosphate backbone is replaced by a neutral N-(2-aminoethyl) glycine ...

Guanine quadruplexes (G-quadruplexes or G4s) are unusual nucleic acid structures with distinct biological and chemical functions. They have occupied significant attention in the nucleic acid world ...

Nucleic acids are complex biological molecules that store and transmit genetic information in all living organisms. They are essential for the survival and reproduction of life on Earth. The two main ...

Since the discovery of the double-helical structure of DNA and postulation of the central dogma of molecular biology, stating that the flow of genetic information goes from DNA to RNA to protein, the ...

image: Researchers at Arizona State University successfully applied microcrystal electron diffraction, or MicroED, to determine the structure of DNA. The results have been published in the journal ...

As a molecular biologist, I always enjoy reading articles concerning DNA and RNA. Your excellent article in the April 3, 2023, issue of C&EN (page 18) titled “The Promise of Peptide Nucleic Acids” ...

The biosecurity risks associated with an unregulated industry became evident when, in 2006, a Guardian reporter successfully ordered parts of the smallpox genome through the mail. Although ordering ...

Scientists at Stanford University have discovered that DRT3, a unique defense system found in bacteria, creates DNA to ...

A loss of TET enzymes, which demethylate DNA, may cause cancer. In TET deficient mice, DNA forms strange structures called G-quadruplexes (G4s) and R-loops that may drive cancer development, a ...

Liquid biopsies contain vast amounts of molecular identifiers that can be used in diagnostic, prognostic and therapeutic applications. Micro RNAs (miRNA) found in bodily fluids, such as plasma, are a ...

This study characterizes several novel activities of SARS-CoV-2 helicase nsp13, providing valuable insights into potentially new functions of this essential RNA-processing enzyme in the virus life ...