DNA replication stress threatens genome stability, but how plants respond to this challenge remains unclear. Here we show that the evolutionarily conserved polymerase ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

While the central dogma of molecular biology outlines the linear flow of genetic information from DNA to RNA to proteins (black lines), glycomics introduces a “3rd code of life”—glycans—that operates ...

Inside our bodies, there is a "molecular clock" that quietly counts how many times a cell can divide. It is the "telomere," a ...

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment has been the focus of a 30-year research question. New work from the Crick ...

At the scale of individual cells, the human body is constantly in motion. Every second, millions of cells divide, particularly in tissues such as the bone marrow, intestine and skin; neurons and heart ...

Scientists at the University of Leicester have captured the first detailed "molecular movie" showing DNA being unzipped at the atomic level – revealing how cells begin the crucial process of copying ...

A new review in the Journal of Translational Medicine consolidates how the replication-initiation protein ORC1 safeguards ...

The discovery of a protein that can, by itself, dictate the sequence of nucleic acids has caused a stir in the scientific community. Commentaries accompanying the work have highlighted the unusual ...