Something else we now know is the Lions will play the Buffalo Bills on Thursday Night Football for their Week 2 game on Thursday, Sept. 17. That matchup will be the first game played at Highmark Stadium, Buffalo's new $2.2 billion home. We know the Lions' 17 opponents include seven games against 2025 playoff teams.

Detroit Lions face a defining early test as they battle the Buffalo Bills in a prime time Week 2 showdown—could this set the tone for a championship run?

The Buffalo Bills have snagged a former Detroit Lions tight end, who will face his old club immediately this season in Week 2.

The Lions’ week-by-week matchups are set to be officially revealed as part of the NFL’s televised schedule release Thursday (May 14) at 8 p.m. EST.

On Tuesday, during voluntary workouts, the Buffalo Bills officially signed tight end Shane Zylstra, who last played for the Detroit Lions.

The Buffalo Bills brought on a former playmaker from the Detroit Lions on Tuesday, potentially adding more support for Josh Allen.

The Detroit Lions schedule 2026 release comes tonight. Here are all the leaks, rumors and announcements in one place.