Intrinsic apoptosis is controlled by the BCL-2 family of proteins but the complexity of intra-family interactions makes it challenging to predict cell fate via standard molecular biology techniques.

Since antiapoptotic Bcl-2 proteins, which potently block the intrinsic apoptosis pathway, are found at elevated levels in human cancers of both hematological and nonhematological origin (Cotter ...

Cellular apoptosis involves condensation of the nucleus and cytoplasm, chromosomal cleavage, and plasma membrane blebbing. 5 It was the first type of programmed cell death to be described by ...

Key findings from the study include: BID is essential for PIDDosome-induced caspase-2-mediated apoptosis. Caspase-2 directly cleaves BID, which then signals the mitochondrial pathway leading to ...

High expression of both pro- and antiapoptotic genes predicted poor OS, which postulates a mechanism of activation of the apoptosis pathway as a whole. This mechanism, which culminates in a three-gene ...

In the intrinsic pathway cellular stress, once detected, causes the cell to self-initiate apoptosis. In the extrinsic pathway, apoptosis is initiated by external signals from other cells.

Extrinsic apoptosis is induced by binding of a death ligand with the death receptor on a diseased cell (demonstrated in the animation below). In contrast, intrinsic apoptosis is initiated in response ...

The intrinsic molecular pathways are also known as mitochondrial or Bcl-2-regulated pathways because they require a bid for apoptosis. This mechanism is associated with the activation of caspase-8 ...

Apoptosis is an important cellular process that allows cells to die in a programmed fashion, essential for embryo development, homeostasis, and cancer development. This 3D animation provides an ...

Up to the 1980s, cell death caused by drugs, chemicals, and other pathophysiologies was primarily considered necrosis. This view radically changed with the discovery of apoptosis and its specific ...

Activated Intrinsic Apoptosis Pathway Is a Key Related Prognostic Parameter in Acute Myeloid Leukemia. JCO 25 , 1209-1215 (2007). DOI: 10.1200/JCO.2006.08.4061 ...