Obesity associated with hypothalamic dysfunction was initially described in patients with craniopharyngioma. Hypothalamic obesity may also result from brain radiation, infection (eg, tuberculosis), ...

Hypothalamic obesity (HyOb) develops when brain damage or conditions like Prader-Willi syndrome disrupt the hypothalamus, impairing hunger and energy regulation. Traditional calorie-based weight-loss ...

Metabolic syndrome (MetS) is a multifaceted disorder that impacts approximately 20–25% of the global population. This syndrome encompasses a range of conditions, including obesity, type 2 diabetes ...

-- First and only FDA-approved therapy for the treatment of acquired hypothalamic obesity, a rare disease characterized by accelerated and sustained weight gain caused by hypothalamic injury or ...

Disruption of the brain’s hunger and satiety control mechanisms can lead to rapid weight gain that is difficult to treat with conventional dietary interventions because patients do not experience an ...

The hypothalamus is a compact but heterogeneous brain region that orchestrates vital homeostatic and behavioural functions including stress responses, energy balance, thermoregulation and circadian ...

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