Medically reviewed by Mary Choy, PharmD Key Takeaways Nicotine has a half-life of about two hours and can stay in the blood for about one to three days. Cotinine, a byproduct of nicotine, has a ...

Nicotine is a highly addictive substance found in all tobacco products, including cigarettes, pipes, cigars, chewing tobacco, and snuff. E-cigarettes and vapes contain nicotine as well. While nicotine ...