Ovarian cancer is the deadliest gynecologic malignancy globally and is increasing in incidence and mortality with currently ...

"The vast majority of patients who are diagnosed with a high-grade serous carcinoma are diagnosed at an advanced stage, and most cancers will recur," Brubaker said of the most common subtype ...

Researchers at Peter Mac have uncovered potential new heredity genes that might be responsible for causing one of the most ...

and high-grade serous carcinoma (HGSC). Its expression is often linked to increased invasiveness and metastatic potential of tumors, making it a critical focus for understanding cancer biology and ...

to characterize chemotherapy resistance mechanisms in ovarian high grade serous carcinoma. The ultimate goal of our cross-disciplinary research is to translate these multi-modal data into testable ...

Brinegar, S. Hawkins, A. Milosavljevic, M. Matzuk, and L. Yen. A recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma. Proc ...

Low-grade serous ovarian cancer is highly recurrent and less sensitive to chemotherapy compared with high-grade serous ovarian cancer and approximately 6,000 to 8,000 women in the United States — as ...