New research results are expanding our understanding of the physiological role of the glial cell line-derived neurotrophic factor GDNF in the function of the brain's dopamine systems. In a new article ...

Four different glial cell line-derived neurotrophic factor (GDNF)-family ligand (GFL)– receptor (GFRα) binding pairs exist, and they all signal through the transmembrane RET receptor tyrosine kinase.

Ten years ago, a glial cell line–derived neurotrophic factor (GDNF) that has prominent actions on nigral dopaminergic neurons, both in vitro and in animal models of Parkinson disease (PD), was ...

Protection Against High-Fat Diet-Induced Obesity – GDNF-tg mice exhibited significantly lower body weight and reduced fat deposition despite consuming a high-fat diet. Enhanced Fat Burning and Energy ...

The major goal of the research of Dr. Sidorova’s team in the Saarma lab is to develop neuroprotective and neuroregenerative drugs for disease-modifying treatment of nervous system disorders caused by ...

For the first time, researchers have witnessed dopaminergic neuron sprouting in a Parkinson disease (PD) patient treated with the neurotrophic factor GDNF. A postmortem examination of the brain of a ...

NEW YORK, Feb. 10, 2026 /PRNewswire/ -- Hoth Therapeutics, Inc. (NASDAQ: HOTH), a patient-focused biopharmaceutical company developing innovative therapies for unmet medical needs, today announced ...

Pfizer has struck a deal with MedGenesis Therapeutix to license its glial cell line-derived neurotrophic factor (GDNF) protein and convection enhanced delivery (CED) technology to investigate ...

GDNF has been hailed as a potential breakthrough for Parkinson’s ever since it was discovered in 1993. In the lab, it was shown to bring dying brain cells back to life and it has proved to be ...

New research results are expanding our understanding of the physiological role of the glial cell line-derived neurotrophic factor GDNF in the function of the brain's dopamine systems. In an article ...