Traditional bisulfite sequencing damages DNA, while enzyme-based alternatives are inconsistent. A novel methylation analysis method, called UMBS-seq, has been published in Nature Communications.
Researchers showed that whole-genome bisulfite sequencing, EM-seq, and the biomodal evoC kit are all feasible for DNA methylation profiling of low-input archival FFPE triple-negative breast cancer ...
Somatic mutations, the DNA changes that occur as our bodies grow and age, not only hold an important key to cancer but are emerging as the seeds of a wide range of common, noncancerous diseases. The ...
When you hear the term "whole-genome sequencing," don't you feel like it allows for a detailed examination of all the DNA ...
Researchers at Beijing Genomics and IMDEA Nanociencia institutes have introduced a novel method that could significantly accelerate efficiency and reduce the cost of handling fluidics in DNA ...
A new method called ReadsRatio estimates tissue contributions to circulating cell-free DNA from unmethylated read ratios in ...
Have you ever come across the term "NGS" in articles about cancer gene panel testing or whole-genome analysis?NGS is a technology that reads DNA base sequences in large quantities.While conventional ...
In a way, sequencing DNA is very simple: There's a molecule, you look at it, and you write down what you find. You'd think it would be easy—and, for any one letter in the sequence, it is. The problem ...
DNA methylation is a highly studied epigenetic modification that is involved in regulating genome function and plays fundamental roles in development and disease. 1 It is linked to a broad range of ...
Researchers at the University of Toronto have invented a new method that uses DNA sequencing to measure metabolites. This enables rapid and precise analysis of biological compounds, such as sugars, ...
Two identical sisters came into the world carrying the same rare cancer. They lost their lives to an undifferentiated sarcoma, a soft-tissue cancer driven by a unique gene fusion (MN1::ZNF341). The ...
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