When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular aging, cancer, ...

The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...

MSK researchers are shedding new light on G-quadruplexes, a type of secondary DNA structure that can cause DNA replication to stall. The structures are a potential therapeutic target in cancer. Image ...

A team of researchers has generated one of the most detailed 3D maps of human chromosomes, cataloging over 140,000 DNA looping interactions.

It's a common storytelling trope: the stubborn foe who is eventually revealed to be a much-needed friend. Biology has its own ...

Researchers have discovered how cells activate a last-resort DNA repair system when severe damage strikes. When genetic ...

One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published ...