Proteins that trigger cell senescence occupy much of the literature on aging, but a small RNA moves into the limelight. Kamal is a freelance science journalist based in the UK with a PhD in virology ...

F. Passos et al., "Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence," PLoS Biology, 5:1138, 2007. (Cited in 31 papers) The study: To investigate why ...

one of which involves permanent cell-cycle arrest — that’s senescence. The cells basically stop dividing and they start producing molecules that disrupt the function of neighboring cells and ...

Immortalized cell lines are derived from cancer cells or genetically modified to overcome senescence, allowing them to proliferate ... and disease modeling. 3D cell cultures involve growing cells in a ...

The intrinsic factor of cell senescence, PCBP2, was identified by unlabeled quantitative proteomics, and its biological role in in vitro replication senescence of human bone marrow mesenchymal stromal ...