α-Alkylation of carbonyl compounds is one of the most useful carbon-carbon bond-forming methods in organic synthesis. Typically, alkylation reactions are achieved by regioselective abstraction of ...
The reaction utilizes an iron catalyst together with an N-heterocyclic carbene (NHC) ligand, which suppresses unwanted side reactions to promote highly selective nucleophile addition. In organic ...
When synthesizing new compounds, it is advantageous to have reactants that are widely available and a simple method which produces a high yield of products with little waste (undesirable byproducts).
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