The islets of Langerhans are the regions of the pancreas that contain cells that produce hormones. There are five types of cells in the islets of Langerhans: beta cells secrete insulin; alpha ...

Dr. Perrier: "We are getting closer to the goal of developing a standard treatment for diabetes that could one day make ...

To investigate the mechanisms of beta cell loss in T2D, researchers at the DZD performed single-cell RNA sequencing of islets of Langerhans in two obese mouse strains that differ in their ...

AI-powered ChemPerturb-seq reveals sex-specific cocktail improving islet transplant survival, offering a new treatment for ...

In the pancreas, islet cells thrive in clusters and are the cellular constituents that exist in alpha and beta forms. They make up the islets of Langerhans, defined groups of cells within the ...

Insulin-producing cells, also called beta cells, are located in regions of the pancreas called islets of Langerhans.They are present in clusters of cells that produce other hormones involved in ...

A pretreatment step could help transplanted pancreatic islets survive longer in patients with type 1 diabetes, according to a ...

While other mechanisms for beta cell loss need to be considered, these findings also seem to suggest that the phenomenon of islet cell loss may be a key driver of senile diabetes.

image: (top left and right) Two different ways in which islet cell loss can be observed. (bottom left) The relationship between the percentage of pancreatic beta cells and islet cell loss.

They transplanted human islets containing beta cells into the kidneys of live mice that lacked an immune system. For 3 months, the scientists gave the mice harmine and exendin-4.

Sander now plans to use vascularized SC-islet organoid models to study Type-1 diabetes, which is caused by immune cells attacking and destroying beta cells in the pancreas – in contrast to Type ...

One-year data suggest allogeneic stem cell-derived islet-cell therapy could become a future option for those with type 1 ...