Detroit tallied a blowout road victory over the Chicago Bears in Week 17, while the San Francisco 49ers fell to the Miami Dolphins on the road last week. The Lions can clinch the

No. 2 pick Jayden Daniels and the Commanders are favored by 4.5 points in the Week 17 NFL odds, over No. 8 pick Michael Penix and the Falcons. Before that, however, a pair of veteran quarterbacks in Jordan Love and Sam Darnold will face off in Packers vs.

The Detroit Lions can move one step closer to tying up top spot in the National Football Conference when they travel to the San Francisco 49ers in a

NFL Week 17 odds, picks, predictions, TV channel, streaming information for Monday Night Football game between Detroit Lions and San Francisco 49ers.

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