The Duke Blue Devils face the Houston Cougars in the Final Four of the men’s NCAA Tournament at the Alamodome in San Antonio, Texas, on Saturday, April 5, 2025.

The Auburn Tigers and Florida Gators meet in an all-SEC clash to kick off the Final Four on Saturday. Then, the Duke Blue Devils square off with the Houston Cougars in the nightcap in San Antonio. Each battle between No. 1 seeds could produce games that are talked about for decades.

Take a look at the point spread, moneyline and over/under (point total) for both Final Four NCAA Tournament men's college basketball games, courtesy of BetMGM Sportsbook.Start the day smarter. Get all the news you need in your inbox each morning.

The NCAA Tournament is drawing to a close for men's basketball. Here are American-Statesman staff March Madness picks for the Final Four predictions.

Cinderella will not be found at the Final Four. Instead, the favorites are headed to the last weekend of the 2025 men's NCAA tournament.

Houston's basketball team is in the Final Four. The Cougars have a massive matchup coming against the Duke Blue Devils.

Tennessee veterans Zakai Zeigler and Jahmai Mashack were part of the Volunteers team that lost to Purdue in the Elite Eight last year. They could have left to explore their professional basketball opportunities, but decided to return to Tennessee for another opportunity like the one they have today.

Madness odds for Houston Cougars vs Duke Blue Devils Final Four NCAA Tournament game, including point spread, moneyline, over/under for betting.